Table L.1.
PFOS serum levels at age 5 vs. diphtheria antibody titres (log 2) at age 7
| Deciles | PFOS (ng/mL) | N | Mean | SD | t‐test | %change |
|---|---|---|---|---|---|---|
| p‐value | ||||||
| 1 | 10.3 | 43 | 0.17 | 1.7 | Referent | |
| 2 | 12.7 | 43 | 0.33 | 1.9 | 0.69 | 11 |
| 3 | 14.2 | 43 | –0.41 | 2.1 | 0.17 | –33 |
| 4 | 15.6 | 43 | 0.27 | 1.7 | 0.79 | 7 |
| 5 | 16.6 | 43 | –0.42 | 1.9 | 0.12 | –34 |
| 6 | 18.2 | 43 | –0.54 | 1.9 | 0.07 | –39 |
| 7 | 19.8 | 43 | 0.09 | 1.8 | 0.22 | –6 |
| 8 | 21.3 | 43 | –0.41 | 2.0 | 0.16 | –33 |
| 9 | 23.6 | 43 | –0.19 | 2.1 | 0.37 | –22 |
| 10 | 28.4 | 43 | –0.59 | 1.8 | 0.048 | –41 |
| Quintiles | PFOS (ng/mL) | N | Mean | SD | t‐test | %change |
|---|---|---|---|---|---|---|
| p‐value | ||||||
| 1 | 11.5 | 86 | 0.25 | 1.81 | Referent | |
| 2 | 14.9 | 86 | –0.07 | 1.91 | 0.32 | –20 |
| 3 | 17.4 | 86 | –0.48 | 1.89 | 0.01 | –40 |
| 4 | 20.6 | 86 | –0.16 | 1.90 | 0.15 | –25 |
| 5 | 26.0 | 86 | –0.39 | 1.94 | 0.03 | –36 |
Yellow highlighted text = NOAEC; Blue highlighted text = LOAEC.
Total number of individuals in these analyses = 431. Divided into deciles: ~ 43 and quintiles ~ 86. Mean and standard error provided on log‐2 scale SD derived. p‐value: t‐test (assuming log‐normal distribution). % change estimated based on mean difference relative to the lowest (referent) decile corresponds to % shift on median concentration on the original (back‐transformed scale). Mean and SD pooled (from deciles) to estimate NOAEC in quintiles.