Table M.13.
Models comparison between the MDH toxicokinetics and applied PBPK models for PFOA
| Parameters | MDH (1 compartment model) | PBPK |
|---|---|---|
| Language | Excel | Berkeley Madonna |
| Body weight | According to US EPA | According French survey |
| Volume of distribution in children | Adjusted between 0 and 10 years | none |
| Volume of distribution in adult | 0.17 L/kg | – |
| Milk volume consumption | < 1 month (510 mL/day), 1 to < 3 month (690 mL/day), 3 to < 6 month (770 mL/day), 6 to < 12 month (620 mL/day) | 800 mL/day |
| Decline in PFOA concentration | None | 0.077 |
| Placenta transfer | 0.87 | 0.77 |
| Milk/serum ratio | 0.052 | 0.03 |
| Intake | Water consumption and breastfeeding | Oral intake and breastfeeding (water consumption, dermal, inhalation but not used in modelling; water part of oral intake) |
| Body weight change during pregnancy | none | none |
| Maternal age when breastfeeding begins (year) | 30 | 35 |
| Model evaluation | Serum level at delivery, infant serum level at birth and at 6 months from Fromme et al. (2010): observed/predicted value within a factor 2 | Serum level at delivery, infant serum level at birth and at 6 months from Fromme et al. (2010): observed/predicted value within a factor 2 |