FIGURE 8.

Effect of rAPN on LPS‐induced lung histopathology score. Total lung histopathology scores were determined for PND4 rats who were given saline or rAPN IP 4 hr before, and 24 hr after IPh LPS (prevention protocol) or given rAPN 20 hr and 48 after IPh LPS (rescue protocol). The lung was removed and processed for histology 72 hr after initial LPS exposure in both protocols. rAPN given before LPS reduced the histopathology score while rAPN given 20 hr after LPS did not. Bars represent mean ± SD one‐way ANOVA followed by post hoc analyses using Tukey's test to compare scores between groups in the prevention protocol and rescue protocol separately. * represents p < .02 saline versus saline + LPS and rAPN alone. ⁺ represents p = .003 versus saline + LPS in the prevention protocol; N = 4 in each group. Four treatment groups were in the prevention protocol while only three treatment groups were in the rescue protocol