Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Sep 21;12:142. doi: 10.1186/s13148-020-00937-y

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 3 — Difference of demethylated genes between DAC-treated clones. a Comparison of DNA methylation levels between DAC-treated clones. A large fraction of genomic blocks showed different methylation levels between the two clones compared. b Unsupervised hierarchical clustering analysis using DNA methylation profiles of 1039 TSS200CGIs fully methylated in HCT116. Demethylated genes were highly diverse among the DAC-treated clones. c DNA methylation status of genes involved in colon cancer-related pathways. Genes involved in cell cycle regulation, the WNT pathway, the p53 pathway, and the TGF-β pathway were completely demethylated, depending upon clones. d Protein expression levels of DKK3 and SFRP1 in DAC-treated clones. Complete demethylation led to the upregulation of methylation-silenced genes at the protein level in DAC-treated clones