. Author manuscript; available in PMC: 2021 Aug 1.

Published in final edited form as: J Am Geriatr Soc. 2020 Aug;68(Suppl 3):S45–S53. doi: 10.1111/jgs.16735

Table 2.

SNPs with at Least One Nominally Significant Association in LASI-DAD (P ≤ .05), and APOE ε2 and ε4 Alleles

SNP	Gene	GWAS study	Risk allele	Risk AF	Chr	Position	Total Learning Score				Delayed Recall Score
							Model 1		Model 2		Model 1		Model 2
							β	P value	β	P value	β	P value	β	P value
rs2830500	ADAMTS1	Kunkle et al⁹	C	0.77	21	28,156,856	−.66	.019	−.5	.059	−.44	.001	−.38	.003
rs10948363	CD2AP	Lambert et al⁸	G	0.20	6	47,487,762	.62	.025	.52	.041	.4	.002	.35	.004
rs9473117	CD2AP	Kunkle et al⁹	C	0.18	6	47,431,284	.57	.064	.48	.091	.4	.006	.36	.009
rs4147929	ABCA7	Lambert et al⁸	A	0.20	19	1,063,443	.55	.062	.67	.015	.24	.095	.29	.03
rs3752246	ABCA7	Kunkle et al⁹	G	0.20	19	1,056,492	.51	.098	.59	.037	.2	.169	.24	.078
rs1859788	ZCWPW1	Jansen et al¹⁰	G	0.72	7	99,971,834	−.59	.018	−.41	.072	−.1	.418	−.03	.817
rs6733839	BIN1	Lambert et al⁸ and Kunkle et al⁹	T	0.41	2	127,892,810	−.43	.059	−.44	.034	−.18	.096	−.19	.065
rs4663105	BIN1	Jansen et al¹⁰	C	0.49	2	127,891,427	−.39	.078	−.43	.036	−.18	.092	−.20	.050
rs7185636	IQCK	Kunkle et al⁹	T	0.69	16	19,808,163	−.59	.017	−.53	.021	−.10	.379	−.08	.445
rs11218343	SORL1	Lambert et al,⁸ Kunkle et al,⁹ and Jansen et al¹⁰	T	0.92	11	121,435,587	−.83	.046	−.89	.02	−.56	.005	−.58	.002
rs429358	APOE	ε4	C	0.10	19	45,411,941	−.30	.438	−.20	.572	−.15	.383	−.12	.487
rs7412	APOE	ε2	C	0.95	19	45,412,079	−.49	.36	−.19	.702	−.17	.516	−.04	.877

Note: P ≤ .05 is indicated by bold text. Effects sizes (β values) are calculated with respect to the Alzheimer’s disease risk allele.

Abbreviations: AF, allele frequency; Chr, chromosome; GW AS, genome-wide association study; LASI-DAD, Longitudinal Aging Study in India–Diagnostic Assessment of Dementia; SNP, single-nucleotide polymorphism.