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. 2020 Sep 21;8(2):e001048. doi: 10.1136/jitc-2020-001048

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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CXCL14-related changes in tumor growth are T cell dependent. (A) Line plot shows growth of mouse oral cavity (MOC)1-derived tumors with and without CXCL14 knockdown after depletion of T cells. (B) Line plot shows growth of MOC2-derived tumors with and without CXCL14 overexpression after depletion of T cells. The effect of CXCL14 modulation is significantly diminished and no longer reaches statistical significance. (C) Plots show fluorescence corresponding to cell surface expression of H-2Db. CXCL14 knockdown in MOC1 cells resulted in a significant decrease in H-2Db (left panel), while CXCL14 overexpression in MOC2 cells did not result in a significant change (right panel). (D) Plots show fluorescence corresponding to cell surface expression of H-2Kb. CXCL14 knockdown in MOC1 cells resulted in a significant decrease in H-2Kb (left panel), while CXCL14 overexpression in MOC2 cells did not result in a significant change (right panel).