Table 2.
Pregnancy outcome and treatment in seronegative and seropositive APS
|
Seronegative APS pregnancies (n=108) |
Seropositive APS pregnancies (n=75) |
|
|---|---|---|
| APS features | ||
| Thrombotic APS | ||
| Arterial APS (n; %) | 0 | 20 (27)† |
| Venous APS (n; %) | 8 (7) | 42 (56)† |
| Obstetrical APS (n; %) | 93 (86) | 36 (48)† |
| Mix APS (n; %) | 6 (6) | 18 (24)† |
| Non-criteria features (n; %) | 18 (17) | 34 (45)† |
| Previous obstetrical history | ||
| Miscarriages (n; %) | 49 (45) | 8 (11)† |
| Intrauterine deaths (n; %) | 29 (27) | 16 (21) |
| Prematurity <34 weeks of gestation (n; %) | 24 (22) | 14 (19) |
| Subsequent pregnancy treatments | ||
| Aspirin (n; %)/aspirin alone | 95 (88)/32 (30) | 57 (76)†/2 (3)† |
| LMWH isocoagulant amounts (n; %) | 63 (58) | 39 (52) |
| LMWH curative amounts (n; %) | 2 (2) | 33 (44)† |
| Aspirin-LMWH (n; %) | 65 (60) | 55 (73) |
| Prednisone (n; %) | 10 (9) | 4 (5) |
| Hydroxychloroquine (n; %) | 10 (9) | 8 (11) |
| Venous thrombosis (n; %) | 0 | 1 (1) |
| Pregnancy outcome | ||
| Preeclampsia/HELLP syndrome (n; %) | 7 (7) | 12 (16)† |
| Intrauterin growth restriction (IUGR) (n; %) | 5 (5) | 7 (10) |
| Oligoamnios (n; %) | 2 (2) | 1 (1) |
| Fetal loss (n; %) miscarriage/intrauterine deaths |
33 (31) 23 (21)/5 (5) |
22 (29) 11 (15)/11 (15)† |
| Prematurity <34 weeks of gestation (n; %) | 6 (6) | 9 (12) |
| Term of fetal loss (weeks of gestation) | 10±8 | 13±7 |
| Live births (n; %) | 75 (69) | 53 (70) |
| Term of live birth (weeks of gestation) | 38±3 | 36±3† |
†p<0.05.
Values are numbers with frequencies and means with SD.
APS, antiphospholipid syndrome; HELLP, hemolysis, Elevated Liver enzymes and Low platelet count; LMWH, low-molecular weighted heparin.