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The Extent of the Defect in the Interferon (IFN) System Correlates with Its Clinical Impact.
IFN-I receptor (IFNAR) deficiency, selectively impairing IFN-I, results in susceptibility to a more limited range of viruses than signal transducer and activator of transcription (STAT)1 deficiency, which disables responses to all IFNs. STAT2 and interferon regulatory factor 9 (IRF9) deficiencies, impeding both IFN-I and IFN-III responses, are intermediate.
