Table 3.
Cytochrome P450 substrates, inhibitors and inducers
| Function | CYP1A2 | CYP2C19 | CYP2C9 | CYP2D6 | CYP2E1 | CYP3A4 |
|---|---|---|---|---|---|---|
| Substrates of isoenzyme | amitriptyline | amitriptyline | amitriptyline | paracetamol | calcium channel blockers | |
| clozapine | NSAIDsa | codeine | carbamazepine | |||
| imipramine | diazepam | ethanol | erythromycin | |||
| imipramine | metoprolol | halothane | ||||
| propanolol | lansoprazole | losartan | oxycodone | isoflurane | fentanyl | |
| theophyline | omeprazole | paroxetine | isoniazid | midazolam | ||
| warfarin | phenytonin | phenytonin | tramadol | |||
| warfarin | simvastatin | |||||
| Inhibitors of isoenzyme | cimetidine | cimetidine | amiodarone | amiodarone | disulfiram | amiodarone |
| ciprofloxacin | SSRIsb | fluconazole | chlorpheniramine | cimetidine | ||
| citalopram | lansoprazole | SSRIsb | SSRIsb | grapefruit juice | ||
| diltiazem | omeprazole | metronidazole | haloperidol | omeprazole | ||
| erythromycin | verapamil | |||||
| trimethoprim | sertraline | |||||
| Inducers of isoenzymes | carbamazepine | carbamazepine | phenobarbitone | chronic ethanol | carbamazepine | |
| tobacco | norethindrone | rifampicin | isoniazid | rifampicin | ||
| tobacco | rifabutin |
a
Non-steroidal anti-inflammatory drugs.
b
Selective serotonin reuptake inhibitors.