TABLE 2: Pathophysiological stages of the evolution of coronavirus disease.

STAGES	DESCRIPTION
Viral endotheliits	● diffuse multisystemic endothelial lesion caused by the virus
	● diffuse endotheliitis
	● microvascular stasis due to endotheliitis
Progressive thrombosis	● platelet aggregation, microvascular thrombosis
	● inflammation and thrombosis of larger vessels, intravascular coagulation;
Diffuse ischemia	● multisystemic ischemia, SIRSa and DIVCb
	● refractory shock, MOFc and death

Each stage of disease progression is presented on the left, with the main events listed on the right. (a) SIRS: Systemic inflammatory response syndrome; (b) DIVC: Disseminated intravascular coagulation; (c) MOF: Multiple organ failure.