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. 2020 Sep 4;11:1074. doi: 10.3389/fphys.2020.01074

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Copyright © 2020 Xue, Sun, Xu, Wang, Guo, Li, Cheng, Xu, Tang, Sun and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Renal tubular EMT and apoptosis and MAPK pathway activation were exacerbated in type 2 diabetic kidneys. (A) Representative images of immunohistochemical staining of E-cadherin, Vimentin, and α-SMA in kidney sections. Original magnification = 400. Scale bar = 100 μm. (B) Western blot bands showing E-cadherin, Vimentin, and α-SMA protein expression in the kidney samples. (C) Quantitative analysis of (B), N = 9. (D) Western blot bands showing Bax, Bcl2, and cleaved Caspase 3 protein expression in the kidney samples. (E) Quantitative analysis of (D), N = 9. (F) Western blot bands showing p-p38 MAPK, p38 MAPK, p-JNK, JNK, p-ERK, and ERK protein expression in the kidney samples. (G) Quantitative analysis of (F), N = 9. The data are presented as the mean ± SD. ^* p < 0.05.