TABLE IV.

Intra-Articular HA Clinical Effect Size Versus Other Treatments for OA Knee Pain^*

Comparator	Placebo	APAP	IA Saline Solution†	Celebrex	Naproxen	Ibuprofen	Diclofenac	IA Steroids
IA HA	0.63	0.45	0.34	0.30	0.25	0.19	0.11	0.02

^*HA = hyaluronic acid, OA = osteoarthritis, APAP = acetaminophen, and IA = intra-articular.

^†IA saline solution control = arthrocentesis, dilution with saline solution injection, and prn (as needed) APAP. Adapted, with permission, from: Bannuru RR, Schmid CH, Kent DM, Vaysbrot EE, Wong JB, McAlindon TE. Comparative effectiveness of pharmacologic interventions for knee osteoarthritis: a systematic review and network meta-analysis. Ann Intern Med. 2015 Jan 6;162(1):46-54.