TABLE V.

Placebo Pill, IA Saline Solution, and Oral NSAID Effect Size for Treatment of Knee OA^*

Comparator	APAP	IA Saline Solution	Celebrex	Naproxen
Placebo pill	0.18	0.29	0.33	0.38
APAP		0.11	0.15	0.20
IA saline solution†			0.04	0.09
Celebrex				0.05

^*IA = intra-articular, NSAID = nonsteroidal anti-inflammatory drug, OA = osteoarthritis, and APAP = acetaminophen.

^†IA saline solution control = arthrocentesis, dilution with saline solution injection, and prn (as needed) APAP. Adapted, with permission, from: Bannuru RR, Schmid CH, Kent DM, Vaysbrot EE, Wong JB, McAlindon TE. Comparative effectiveness of pharmacologic interventions for knee osteoarthritis: a systematic review and network meta-analysis. Ann Intern Med. 2015 Jan 6;162(1):46-54.