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. Author manuscript; available in PMC: 2021 May 11.
Published in final edited form as: ACS Biomater Sci Eng. 2019 Oct 29;6(5):2518–2532. doi: 10.1021/acsbiomaterials.9b01067

Table 1:

Summary of approaches used to mimic cardiac diseases

CARDIAC DISORDER Disease-specific cells Disease-inspired physical cues
Dilated cardiomyopathy hPSC-CMs 49 --
Left ventricular hypertrophy hPSC-CMs 51 Increased afterload 6773
Ischemia-reperfusion injury -- Hypoxia 6163
Fibrosis CM/fibroblast ratio 5354 Cyclic strain 79,82
Biomolecules 7881
ECM density 54