. Author manuscript; available in PMC: 2021 May 11.

Published in final edited form as: ACS Biomater Sci Eng. 2019 Oct 29;6(5):2518–2532. doi: 10.1021/acsbiomaterials.9b01067

Table 1:

Summary of approaches used to mimic cardiac diseases

CARDIAC DISORDER	Disease-specific cells	Disease-inspired physical cues
Dilated cardiomyopathy	hPSC-CMs ⁴⁹	--
Left ventricular hypertrophy	hPSC-CMs ⁵¹	Increased afterload ^67–73
Ischemia-reperfusion injury	--	Hypoxia ^61–63
Fibrosis	CM/fibroblast ratio ^53–54	Cyclic strain ^79,82
		Biomolecules ^78–81
		ECM density ⁵⁴