Table1.
Effect of ACAE and ACHE on the macroscopic parameters of colitis induced by acetic acid in rats
| Group/dose (mg/kg) |
Ulcer area (cm2) |
Ulcer score (0-3) |
Ulcer index (0-11) |
Colon weight (mg/cm) |
|---|---|---|---|---|
| Sham | 0.00±0.00 | 0.0 (0-0) | 0.00±0.00 | 79.8±5.1 |
| Control (Colitis) | 5.95±0.43+++ | 3.0 (3-3)+++ | 8.95±0.42+++ | 250.6±7.4+++ |
| ACAE150 | 4.01±0.65 | 3.0 (1-3) | 6.51±0.83 | 229.1±18.6 |
| ACAE300 | 2.05±0.58*** | 1.0 (1-2)** | 3.22±0.74*** | 159.4±12.5*** |
| ACAE600 | 1.68±0.33*** | 1.0 (1-2)** | 3.01±0.53*** | 118.7±7.3*** |
| ACHA150 | 3.43±1.05* | 1.5 (1-3)* | 5.27±1.34* | 146.4±19.5*** |
| ACHA300 | 1.36±0.43*** | 1.0 (0-3)** | 2.53±0.70*** | 104.1±9.9*** |
| ACHA600 | 3.22±0.69* | 2.0 (1-3)** | 5.06±0.97** | 150.0±9.2*** |
| Prednisolone4 | 0.53±0.05*** | 1.0 (1-1)*** | 1.53±0.05*** | 89.6±2.2*** |
| Mesalazine100 | 0.62±0.05*** | 1.0 (1-2)*** | 1.79±0.18*** | 108.8±10.0*** |
Sham: normal rats received normal saline/tween (5 ml/kg/day), Control: rats with colitis received normal saline/tween (5 ml/kg/day), ACAE: A. capillus-veneris aqueous extract (150, 300 and 600 mg/kg), ACHE: A. capillus-veneris hydroalcoholic extract (150, 300 and 600 mg/kg). Data is expressed as mean±SEM or median (range) for scoring parameter, n=6. +++p<0.001 denotes a significant difference versus sham group. *p<0.05, **p<0.01, and ***p<0.001, denote a significant difference versus control.