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. 2020 Jul 31;27(3):dsaa016. doi: 10.1093/dnares/dsaa016

Figure 4.

Figure 4.

Orthologous gene clusters in the terpenoid biosynthetic pathway. The number of corresponding orthologs from each species is indicated by colour gradient intensity. (A) Orthogroups occupied by Arabidopsis thaliana genes involved in the mevalonic acid (MVA) and methylerythriol phosphate (MEP) pathways. MVA pathway leading to sterols and sesquiterpenes: acetyl-CoA acetyltransferase activity (AACT); 3-hydroxy-3-methylglutaryl coenzyme A synthase (HMGS); hydroxymethylglutaryl-CoA reductase (HMGR); ATP: mevalonate phosphotransferase (MK); phosphomevalonate kinase (PMK); mevalonate diphosphate decarboxylase (MDD); isopentenyl diphosphate delta-isomerase (IDI); geranyltranstransferase (FPPS). MEP pathway leading to geraniol, monoterpenes, and diterpenes: 1-deoxy-D-xylulose-5-phosphate synthase (DXS); 1-deoxy-d-xylulose-5-phosphate reductoisomerase (DXR); 2-C-methyl-d-erythritol 4-phosphate cytidylyltransferase (MCT); 4-(cytidine 50-diphospho)-2-C-methyl-d-erythritol kinase (CMK); 2-C-methyl-d-erythritol 2,4-cyclodiphosphate synthase (MDS); 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (HDS); 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase (HDR); geranylgeranyl pyrophosphate synthase large subunit (GGPPS-LSU); geranyl pyrophosphate synthase small subunit (GPPS-SSU). Terpene synthase subfamilies: TPS a, b, c, g, e/f. (B) Orthogroups occupied by A. thaliana and Lamiaceae terpene synthase genes. Orthologous groups specific to A. thaliana are shown to the right of the red divider line; singletons are denoted by an ‘*’ following the gene ID.