Table 2. Uni- and multivariate Cox-regression analysis for the prediction of overall survival.
| univariate Cox-regression | multivariate Cox-regression | |||
|---|---|---|---|---|
| Parameter | p-value | Hazard-Ratio (95% CI) | p-value | Hazard-Ratio (95% CI) |
| rel. miR-193a-5p levels >3.57 (dichotomized) | 0.012 | 2.936 (1.273–6.776) | 0.011 | 3.708 (1.354–10.159) |
| Age | 0.464 | 1.015 (0.975–1.057) | ||
| Female sex (dichotomized) | 0.504 | 0.745 (0.315–1.766) | ||
| ECOG PS (0 to 3) | 0.331 | 1.397 (0.713–2.737) | ||
| BMI | 0.712 | 0.986 (0.915–1.062) | ||
| HCC tumor size | 0.164 | 1.071 (0.972–1.180) | 0.307 | 1.061 (0.947–1.190) |
| Tumor grading (G1 to G3) | 0.407 | 1.518 (0.566–4.067) | ||
| Leukocyte count | 0.201 | 1.110 (0.946–1.304) | 0.659 | 1.044 (0.862–1.265) |
| Hemoglobin | 0.347 | 0.996 (0.988–1.004) | ||
| Platelets | 0.511 | 1.001 (0.998–1.003) | ||
| Sodium | 0.306 | 1.057 (0.951–1.175) | ||
| Potassium | 0.374 | 1.431 (0.649–3.159) | ||
| AST | 0.707 | 1.002 (0.991–1.013) | ||
| Bilirubin | 0.399 | 0.753 (0.389–1.457) | ||
| AFP | 0.589 | 1.000 (1.000–1.000) | ||
| Creatinine | 0.358 | 1.708 (0.510–5.724) | ||
| CRP | <0.001 | 1.099 (1.045–1.157) | 0.002 | 1.085 (1.030–1.143) |
miR: microRNA, HCC: hepatocellular carcinoma, ECOG PS: “Eastern Cooperative Oncology Group” performance status, BMI: Body-Mass-Index, AST: aspartate transaminase, AFP: alpha-fetoprotein, CRP: C-reactive protein; dichotomized variables are indicated, other variables were continuous.