Fig 7. Parkin/p53 interference.

DOX induced a deleterious phenotype in WT CFs. Due to the cell’s inability to respond to multiple stressors, an early DCM gene profile was adopted. This included increased cardiac remodeling genes and increased inflammatory signaling. The phenotype also removes the cell’s ability to respond to injury by inhibiting proliferation and migration. Lastly, the cell is open to increased damage as it is unable to respond to metabolic stressors due to mitochondrial dysfunction and deficits in clearing the dysfunctional mitochondria.