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. 2020 Sep 22;15(9):e0239401. doi: 10.1371/journal.pone.0239401

Table 6. Predictors of death or intubation.

Final models using the type of glucocorticoid therapy.

Variable HR (95%CI) p
WHOLE COHORT (n = 242)
Glucocorticoid therapy
 No glucocorticoids reference
 Non-pulse glucocorticoids 3.83 (1.51–9.68) 0.004
 Out-of-week-2-MP 2.06 (0.71–6.00) 0.183
 Week-2-MP 0.28 (0.07–1.12) 0.072
SpO2/FiO2* 0.92 (0.89–0.95) <0.001
CURB65
 Low risk reference
 Intermediate risk 2.38 (1.00–5.65) 0.049
 High risk 3.98 (1.58–9.89) 0.003
PATIENTS WITH SpO2/FiO2 ≤353 (n = 122)
Glucocorticoid therapy
 No glucocorticoids reference
 Non-pulse glucocorticoids 3.06 (1.06–8.85) 0.039
 Out-of-week-2-MP 1.92 (0.61–6.00) 0.263
 Week-2-MP 0.20 (0.04–1.00) 0.050
SpO2/FiO2* 0.88 (0.83–0.93) <0.001
CURB65
 Low risk reference
 Intermediate risk 2.49 (0.91–6.80) 0.075
 High risk 5.00 (1.73–14.47) 0.003

MP: methyl-prednisolone pulses; Week-2-MP: methyl-prednisolone pulses in week 2. HR: hazard ratio; CI: confidence interval.

*HR here estimates change in hazard by 10 units increase in SaO2/FiO2.