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. 2020 Sep 21;11(9):e00202. doi: 10.14309/ctg.0000000000000202

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© 2020 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology

This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work, provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

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Figure 4. — SMAD family member 4 (SMAD4) expression and correlation with clinical outcomes in EAC. (a) Immunohistochemical profile of a case with SMAD4 loss in tumor cells vs normally expressed SMAD4 in non-neoplastic glands and in stromal cells (upper left corner) (hematoxylin was used as a counterstain) (×20). (b) EAC grouped according to cancer with high SMAD4 (<30% loss of protein expression; green bars) and low SMAD4 (>30% loss of protein expression; blue bars) and disease recurrence (Fisher exact test; P = 0.015). EAC, esophageal adenocarcinoma.