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Vaborbactam complex crystal structure with class A carbapenemase KPC-2. (A) Vaborbactam covalently bound in the active site of KPC-2 (1.25-Å resolution; PDB code 6V7I). The unbiased Fo-Fc omit map of vaborbactam is contoured at 3σ and represented with gray mesh. Hydrogen bonds are shown as black dashed lines. (B) Superimposition of KPC-2–vaborbactam (gray) and KPC-2 apo (PDB code 5UL8; purple) structures.
