TABLE 4.

Concentration response of carbenicillin and piperacillin potentiation by vaborbactam and avibactam against KPC-2-producing strains of P. aeruginosa

Plasmid	BLI	Antibiotic	Antibiotic MIC (μg/ml) in the presence of BLI at (μg/ml):							PV50 (μg/ml)
			0	1	2	4	8	16	32
WT	Vaborbactam	Carbenicillin	1,024	64	16	8	4	2	1	1.9
S130G	Vaborbactam	Carbenicillin	128	4	2	1	≤0.5	≤0.5	≤0.5	<1
WT	Avibactam	Carbenicillin	1,024	64	64	32	16	8	2	4.6
S130G	Avibactam	Carbenicillin	128	128	128	64	64	64	32	>150
WT	Vaborbactam	Piperacillin	128	1	0.5	0.25	≤0.13	≤0.13	≤0.13	<1
S130G	Vaborbactam	Piperacillin	128	2	0.5	0.25	0.25	≤0.13	≤0.13	<1
WT	Avibactam	Piperacillin	128	2	1	0.5	0.25	≤0.13	≤0.13	<1
S130G	Avibactam	Piperacillin	128	128	64	64	64	32	16	>100