TABLE 8.
Percent susceptible to cefiderocol, ceftazidime-avibactam, and eravacycline in relation to susceptibility or resistance to comparator agents among 343 carbapenem-resistant Escherichia coli study isolates
| Comparator agenta,b | No. susceptible to agent (% of 343) | CFDC susceptiblea |
Pc | CZA susceptiblea |
Pc | ERV susceptiblea (%) |
Pc | |||
|---|---|---|---|---|---|---|---|---|---|---|
| Susceptible to comparator (%) | Resistant to comparator (%) | Susceptible comparator (%) | Resistant to comparator (%) | Susceptible to comparator (%) | Resistant to comparator (%) | |||||
| CFDC | 315 (92) | n.a. | n.a. | n.a. | 272/315 (86) | 9/28 (32) | <0.001 | 309/315 (98) | 26/28 (93) | |
| CZA | 281 (82) | 272/281 (97) | 43/62 (69) | <0.001 | n.a. | n.a. | n.a. | 276/281 (98) | 59/62 (95) | |
| ERV | 335 (98) | 309/335 (92) | 6/8 (75) | 276/335 (82) | 5/8 (63) | n.a. | n.a. | n.a. | ||
| MEM | 203 (59) | 199/203 (98) | 116/140 (83) | <0.001 | 201/203 (99) | 80/140 (57) | <0.001 | 198/203 (98) | 137/140 (98) | |
| IPM | 100 (29) | 98/100 (98) | 217/243 (89) | 0.008 | 100/100 (100) | 181/243 (75) | <0.001 | 100/100 (100) | 235/243 (97) | |
| ETP | 15 (4) | 14/15 (93) | 301/328 (92) | 11/15 (73) | 270/328 (82) | 14/15 (93) | 321/328 (98) | |||
| GEN | 189 (55) | 179/189 (95) | 136/154 (88) | 0.03 | 176/189 (93) | 105/154 (68) | <0.001 | 186/189 (98) | 149/154 (97) | |
| TZP | 72 (21) | 71/72 (97) | 244/271 (90) | 0.02 | 66/72 (92) | 215/271 (79) | 0.02 | 72/72 (100) | 263/271 (97) | |
| AMK | 269 (78) | 255/269 (95) | 60/74 (81) | <0.001 | 239/269 (89) | 42/74 (57) | <0.001 | 263/269 (98) | 72/74 (97) | |
| LVX | 62 (18) | 61/62 (98) | 254/281 (90) | 0.04 | 59/62 (95) | 222/281 (79) | 0.003 | 62/62 (100) | 273/281 (97) | |
| TGC | 340 (99) | 313/340 (92) | 2/3 (67) | 279/340 (82) | 2/3 (67) | 335/340 (98) | 0/3 (0) | <0.001 | ||
| CAZ | 36 (11) | 36/36 (100) | 279/307 (91) | 36/36 (100) | 245/307 (80) | 0.003 | 35/36 (97) | 300/307 (98) | ||
| MIN | 231 (67) | 218/231 (94) | 97/112 (87) | 0.02 | 197/231 (85) | 84/112 (75) | 0.02 | 231/231 (100) | 104/112 (93) | <0.001 |
a
Abbreviations: AMK, amikacin; CFDC, cefiderocol; CAZ, ceftazidime; CZA, ceftazidime-avibactam; CL, colistin; ERV, eravacycline; ETP, ertapenem; GEN, gentamicin; IPM, imipenem; LVX, levofloxacin; MEM, meropenem; MIN, minocycline; n.a., not applicable (comparison with self); TZP, piperacillin-tazobactam; TGC, tigecycline.
b
CL, colistin: not shown; all isolates resistant.
c
P values, as determined by chi-square test, are shown were P < 0.05.