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(A) Sequence analysis of the 14-α sterol demethylase Cyp51A and Cyp51B paralogs in Aspergillus fumigatus reveals potential motifs for endoplasmic reticulum (ER) localization. Cyp51A and Cyp51B each contain four diarginine/dilysine motifs (underlined in green), indicating a potential link to the ER. (B) TMHMM server 2.0 prediction of one transmembrane region each (underlined in red in panel A) in Cyp51A and Cyp51B proteins.
