FIG 1.

Illustration of cochleate technology. Amphotericin B is embedded within the phosphatidylserine bilayers of the cochleate, along with calcium ions. The cochleate protects the cAMB from digestive processes in the gastrointestinal tract until absorbed. Once absorbed, the cochleate is phagocytosed by macrophages. Due to the higher calcium concentration in the cochleate than in the cytoplasm of the macrophage, the cochleate is pulled open as calcium ions rush out, allowing intracellular delivery of the amphotericin B.