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. 2020 Sep 21;64(10):e01178-20. doi: 10.1128/AAC.01178-20

FIG 3.

FIG 3

Lung CFU counts after 2 months of treatment with one-, two-, and three-drug combinations of B, Pa, and L in BALB/c mice infected with M. tuberculosis strains H37Rv or HN878 in experiment 4. (A) Results for combinations using 50 mg/kg Pa q.d. in mice infected with M. tuberculosis H37Rv. (B) Results for combinations using 100 mg/kg Pa q.d. in mice infected with M. tuberculosis H37Rv. (C) Results for combinations using 50 mg/kg Pa q.d. in mice infected with M. tuberculosis HN878. (D) Results for combinations using 100 mg/kg Pa q.d. in mice infected with M. tuberculosis HN878. Abbreviations: B, bedaquiline; Pa, pretomanid; L, linezolid; q.d., once a day (5/7); NA, not available due to contamination of samples. Doses used were as follows: 25 mg/kg B q.d. and 45 or 90 mg/kg L q.d., as indicated.