. 2020 Sep 21;64(10):e01178-20. doi: 10.1128/AAC.01178-20

TABLE 1.

Lung CFU counts assessed during treatment, and proportions of mice relapsing after treatment of BALB/c mice infected with M. tuberculosis H37Rv

Regimen^a	Mean lung log₁₀ CFU count ± SD by time point^b					No. of mice relapsing after treatment for 3 mo
Regimen^a	D-14	D0	M1	M2	M3	No. of mice relapsing after treatment for 3 mo
Untreated	3.90 ± 0.12	7.79 ± 0.24
RHZE			5.33 ± 0.16^c	3.59 ± 0.22^d	1.63 ± 0.14^d
BPa			5.46 ± 0.33^e	4.03 ± 0.32^d	2.28 ± 0.20^d	15/15^d
1BPaL_45q.d./BPa			4.91 ± 0.20^f	2.43 ± 0.44^e^,^g	0.90 ± 0.32^e^,^g
1BPaL_45q.d./BPaL_90q.o.d				2.70 ± 0.41^d^,^g	0.86 ± 0.27^e^,^g	7/15^f
2BPaL_45q.d./BPa				3.04 ± 0.33^d^,^h	0.98 ± 0.43^e^,^g	7/15^f
BPaL_45q.d.					0.59 ± 0.71^g	9/15^c
BPaL_90q.o.d.			5.14 ± 0.28	2.65 ± 0.44^d^,^g	0.54 ± 0.47^g	11/15^e
1BPaL_90q.d./BPa			4.73 ± 0.42^h	1.84 ± 0.33^g	0.41 ± 0.28^g
1BPaL_90q.d./BPaL_90q.o.d.				2.60 ± 0.49^d^,^g	0.25 ± 0.35^g	3/15^g
2BPaL_90q.d./BPa				1.24 ± 0.87^g	0.26 ± 0.39^g	2/15^g
BPaL_90q.d.					0.09 ± 0.19^g	1/15^g

For regimens with two phases, the phases are separated by a slash and the number at the beginning indicates the duration of the initial phase in months. For treatment arms that received the same treatment up to M1 or M2, mice were sacrificed from only one of those arms and used to represent all of the arms receiving the same treatment up to that time point.

Time points are shown as days (D-14 or D0) or months (M1, M2, or M3).

Indicates a significant difference compared with BPaL_90q.d. with a P value of <0.05.

Indicates a significant difference compared with BPaL_90q.d. with a P value of <0.001.

Indicates a significant difference compared with BPaL_90q.d. with a P value of <0.01.

Indicates a significant difference compared with BPa with a P value of <0.05.

Indicates a significant difference compared with BPa with a P value of <0.001.

Indicates a significant difference compared with BPa with a P value of <0.01.