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. Author manuscript; available in PMC: 2020 Sep 23.
Published in final edited form as: J Cardiovasc Pharmacol. 2019 Nov;74(5):436–442. doi: 10.1097/FJC.0000000000000730

FIGURE 3.

FIGURE 3.

Effect of the vehicle and anti-MBG antibody (3E9 mAb) on erythrocyte Na/K-ATPase (A), systolic BP (B), and responsiveness of rat aortic rings to SNP-induced vasorelaxation following contractions induced by 100 nmol/L endothelin-1 (C) in NaCl-loaded DM rats versus control. Effect of the combination of DM2, NaCl, and vehicle and DM2, NaCl, and anti-MBG mAb treatment on plasma MBG (D), LV weight (E), and aortic weight (F). Data presented as mean ± SEM from 8 measurements, except (C), below. By 2-way analysis of variance followed by Bonferroni’s test: *P < 0.05, **P < 0.01 versus controls, #P < 0.05 versus vehicle (A). Concentration-response curves were determined 5–7 times on individual samples pooled and averaged to give means and SEM for IC50 (C).