Supplementary Table 2. Odds ratio (95% confidence interval) of prevalent subclinical cerebrovascular diseases according to per standard deviation (1.13) of coronary artery calcification scores in log scale (ln (CAC + 1)).
| ORs (95% CI) | P value | |
|---|---|---|
| Lacunar infarction | ||
| Unadjusted model | 1.70 (1.40, 2.07) | < 0.001 |
| Age-adjusted model | 1.48 (1.21, 1.81) | < 0.001 |
| Risk factor adjusted model§ | 1.33 (1.07, 1.65) | 0.012 |
| DSWMH | ||
| Unadjusted model | 1.38 (1.17, 1.62) | < 0.001 |
| Age-adjusted model | 1.35 (1.11, 1.63) | 0.002 |
| Risk factor adjusted model§ | 1.38 (1.12, 1.70) | 0.002 |
| PVH | ||
| Unadjusted model | 1.26 (1.08, 1.47) | 0.003 |
| Age-adjusted model | 1.11 (0.92, 1.33) | 0.286 |
| Risk factor adjusted model§ | 1.11 (0.91, 1.35) | 0.304 |
| Microbleeds | ||
| Unadjusted model | 1.24 (1.02, 1.51) | 0.031 |
| Age-adjusted model | 1.15 (0.92, 1.45) | 0.225 |
| Risk factor adjusted model§ | 1.11 (0.87, 1.43) | 0.401 |
| ICAS | ||
| Unadjusted model | 1.71 (1.47, 2.00) | < 0.001 |
| Age-adjusted model | 1.70 (1.42, 2.04) | < 0.001 |
| Risk factor adjusted model§ | 1.54 (1.26, 1.88) | < 0.001 |
In the risk factor adjusted model, a total of 697 observations were analyzed, after excluding those with missing values of explanatory variables.
Adjusting covariates for risk factor adjusted model: age (year), systolic blood pressure (mmHg), antihypertensive medication (2 missing), LDL-cholesterol (mg/dL, 10 missing), HDL-cholesterol (mg/dL, 3 missing), triglycerides (mg/dL, 3 missing), lipid-lowering medication, diabetes (3 missing), smoking, and drinking habits (current, past, never).
Abbreviations: CAC, coronary artery calcification; CI, confidence interval; DSWMH, deep and subcortical white matter hyperintensity; HDL-cholesterol, high-density lipoprotein cholesterol; ICAS, intracranial arterial stenosis; LDL-cholesterol, low-density lipoprotein cholesterol; ORs, odds ratio; PVH, periventricular white matter hyperintensity.
Definitions: Age, assessed at the examination for risk factor and CAC (2010–2014); hypertension, systolic/diastolic blood pressure ≥ 140/90 mmHg or antihypertensive medication use; diabetes, a fasting glucose ≥ 7.0 mmol/L (126 mg/dL) or HbA1c (NGSP) ≥ 6.5% or anti-diabetic medication use; lacunar infarction, number of lesions ≥ 1; DSWMH, grade ≥ 3; PVH, grade ≥ 2; Microbleeds, number of lesions ≥ 1; ICAS, a stenosis of ≥ 1% identified in the basilar artery, plus the following five vessels bilaterally: intracranial segments of the internal carotid artery, the middle cerebral artery, the anterior cerebral artery, intracranial segments of the vertebral artery, and the posterior cerebral artery.