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. 2020 Sep 22;10:15469. doi: 10.1038/s41598-020-72158-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Mechanical strain enhances pluripotency transcription factors in mouse fibroblasts. (A) Thin shims were added to adjust the height of the pistons to apply varying mechanical strain across the plate. Bar = 1 cm. (B) Diagram of one row of pistons displacing the membranes. When the lowest piston is applying 2.5% strain the highest piston is applying 17.5% strain. Mechanical stain was applied at 0.1 Hz for four hours per day for seven days. (C) Expression of Oct-4 eGFP in MEFs after one day of mechanical loading at varying levels of strain. *p < 0.05 versus static control group. (D) Oct-4 eGFP signaling in MEFs after seven days of mechanical load. *p < 0.05 versus static control group.