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. 2020 Sep 22;11:4788. doi: 10.1038/s41467-020-18524-3

Fig. 1. VAV2 mRNA levels correlate with poor prognosis in HPV– hnSCC.

Fig. 1

a Expression of VAV2 mRNA in indicated samples (bottom) and gene expression datasets (top). *P = 0.029 (dysplasia versus healthy, hnSCC), 0.047 (HPV− versus HPV+ hnSCC); **P = 0.005 (psoriasis versus healthy, cSCC); ***P < 0.0001 (all other analyses) using ANOVA and Tukey’s HSD tests (from left to right, n = 220, 229, 155, and 273 patient samples, respectively). When data were generated using two datasets at the same time, we used frozen robust multiarray analyses (fRMA) to avoid batch effects as indicated in Methods. Data represent the mean ± SEM. b Survival of HPV− hnSCC patients according to the abundance of VAV2 and EGFR mRNAs in tumors in indicated datasets (top). The Mantel–Cox test P value is indicated for each transcript. Source data for this figure are provided as a Source Data file.