Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Sep 22;11:4788. doi: 10.1038/s41467-020-18524-3

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 3 — a Histological sections of the epithelia from mice of the indicated genotypes. The thickness of the epithelium is indicated with a bracket. Scale bar, 100 (back and ear skin) and 200 (palate and tongue) μm (n = 6 animals per genotype). b Thickness of indicated epithelial linings according to the data gathered in a. ***P < 0.0001 (two-tailed Student’s t-test, n = 6 animals per genotype). px pixel. c Expression of keratin 5 (K5; top, red color), keratin 6 (K6; bottom, red color), and keratin 10 (K10; both panels, green color) in the skin from the back of animals of indicated genotypes. In all cases, the nuclei of cells were labeled with DAPI (blue color). Scale bar, 50 μm (n = 3). Penetrance (d) and multiplicity (e) of tumors generated in mice of the indicated genotypes upon a single topic DMBA application at postnatal day 3. The differences between genotypes were statistically significant from week 12 onwards (P < 0.0001, two-tailed Student’s t-test). n = 24 and 31 WT and Vav2^Onc/Onc mice, respectively. f Size distribution of the tumors at the endpoint of the experiment shown in d. ***P < 0.0001 (two-tailed Student’s t-test, n as in d). g Tumor type distribution at the endpoint of the experiment shown in d. P < 0.0001 (Chi-squared test, n = 15 and 72 WT and Vav2^Onc/Onc tumors, respectively). In b, e, and f, data represent the mean ± SEM. Source data for this figure are provided as a Source Data file.