Figure 1:
DLMO for the Baependi population (mean is marked with red dotted line) compared with published DLMO data from other adult populations9,28–30,32,35–42. Data are presented as mean±SEM. Different methodologies for determining DLMO are shown as follows: Dynamic threshold refers to defining DLMO based on two standard deviations above the mean of three or more pre-rise values or from parameters describing a fitted curve to the time series of melatonin samples. Fixed threshold refers to analyzing DLMO based on a time of attaining a 1 or 3 pg/ml level for saliva or a comparable 10 pg/ml for plasma. The threshold used in the present study was 3 pg/ml.