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. 2020 Sep 22;11:4782. doi: 10.1038/s41467-020-18507-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a Summary of developmental changes in stability of memory in the model. b Summary of the model and its parameters. PcG: Polycomb group proteins; TrxG: Trithorax group proteins; TFs: transcription factors. Global inputs are those that are expected to affect all PRE/TRE regulated genes in the genome. Local inputs are those that may be regulated specifically for different loci. The output of the model in terms of transcriptional activity depends on the interplay between PRE/TRE state and promoter state. See main text for details.