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. 2020 Sep 22;11:4779. doi: 10.1038/s41467-020-18618-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Scatterplots of cell-type specific t-statistics (as obtained with CellDMC) across four whole blood cohorts (TZH, Liu, Hannum, and Tsaprouni) with associated Pearson Correlation Coefficient (PCC) values, and separately for the lymphoid (left) and myeloid (right) lineages. The t-statistics are displayed for the 62 gold-standard smoking-associated CpGs (60 hypomethylated (orange) and 2 hypermethylated (blue)). b Boxplots of t-statistics of association of DNAm with smoking in the whole blood (n = 689) from Liu et al., as derived with CellDMC for both lymphoid and myeloid lineages. Boxplots only display the 60 gold-standard smoking hypomethylated CpGs from Gao and Brenner. P value derives from a one-tailed Wilcoxon rank sum test. Horizontal line within boxes indicate median, box-boundaries the interquartile range, and whiskers extend to 1.5 times this range. c–e As b, but now for the 656 samples from Hannum et al., the 464 samples from Tsaprouni et al., and the 790 buccal swab samples.