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Haplotypes of the ancestral 419Arg and derived 419Gln alleles at rs1800407 and the enhancer normal (E +) and negative (E-) alleles at rs12913832. The doubly-derived (cis) haplotype has frequency estimates of 1% to 3.6% in 14 European populations (see Table S2).
| 2 SNP haplotype | Eye color effect | |
|---|---|---|
| 419Arg-E + | CA | Ancestral; dark iris color |
| 419Gln-E + | TA | ? |
| 419Arg-E- | CG | Light iris color |
| 419Gln-E- | TG | Light iris color; Doubly-derived/cis |
