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. Author manuscript; available in PMC: 2021 Oct 1.
Published in final edited form as: Nanomedicine. 2020 Jun 12;29:102236. doi: 10.1016/j.nano.2020.102236

Figure 6. PK profile of α-CD99-A192 nanoworms:

Figure 6.

190 μM of α-CD99-A192 labeled covalently with rhodamine in 150 μl/25g B.W. of PBS was injected via tail vein in mice (n=4 mice). Blood was collected and plasma was measured for fluorescence. Rhodamine-labeled α-CD99-A192 plasma concentration was calculated using a standard curve. A) The plasma concentrations were fit to Eq. (6) to obtain the PK curve, and the generated curve shows the rhodamine-labeled α-CD99-A192 concentration in the plasma over 72 hours. After 96 hours from the injection, spleen (S), kidneys (K), and the liver (L) were collected from mice. B-C) Bioluminescence images of organs were obtained 96 hours post-injection and quantified based on the fluorescent intensity obtained from images.