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. 2020 Sep 22;10:15413. doi: 10.1038/s41598-020-72348-1

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Literature survey of insulin response to glucose loading in β-cells. Green represents basal blood glucose concentration (up to 5 mM); yellow represent glucose concentrations, where insulin response is increased compared to the basal condition. The yellow line is drawn at 11.7 mM glucose; red represents glucotoxic conditions where insulin secretion is reduced compared to the basal condition. Numbers refer to literature references. Additional information including cell line and incubation conditions for the referred studies are collected in Tab S1.