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. 2020 Sep 22;10:15413. doi: 10.1038/s41598-020-72348-1

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(A) Sum of measured metabolites relative to an internal standard plotted against the glucose concentration (3 – 35 mM) after 4 h of incubation, n = 4. (B) Glucose consumption (mM) plotted against the glucose concentration after 4 h of incubation measured by UV-assay, n = 4. (C–G) Individual metabolic profiles of ¹³C labelled metabolites contributing to the sum shown in A.