Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Sep 22;10:15413. doi: 10.1038/s41598-020-72348-1

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

(A–C) The two main metabolites lactate and pyruvate and their sum responding over time to various glucose concentrations (11.7, 17 and 35 mM). The sum of pyruvate and lactate did not change significantly over time (p > 0.05, ANOVA followed by Student’s t-tests). (D–F) The corresponding glucose stimulated insulin secretion (GSIS) as a ratio between high and low glucose stimulation (2 and 17 mM glucose respectively) from GSIS experiment carried out after either 2 or 8 h of incubation with the three glucose concentrations (n = 4). No significant change was found, neither as function of time (2–8 h) nor concentration (11.7–35 mM) (p = 0.8 for 11.7 mM, p = 0.5 for 17 mM and p = 0.4 for 35 mM ΔGSIS 2 h vs 8 h, Student’s t-tests). The responses to incubations are similar for all conditions.