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. 2020 Sep 15;37:101728. doi: 10.1016/j.redox.2020.101728

Fig. 4.

Fig. 4

PCB2 improved vascular relaxation impaired by high glucose. C57BL/6J mouse thoracic aortic rings were pretreated with PCB2 (10 μM, 12 h) or vehicle before the exposure to HG (30 mM, 36 h) or mannitol. (A) Representative traces of the ACh-induced relaxation of the Phe-precontracted rings. The dots represented cumulative addition of increasing doses of ACh (5 × 10-10 to 10-5 M). (B) PCB2 ameliorated the ACh-induced relaxations which were impaired by HG. (C) SNP-induced relaxations were not affected by HG. (D) Alternatively, the aortic rings were treated with indomethacin (Indo, 1 μM), ODQ (3 μM) or (E)l-NAME (100 μM) or 1400 W (100 nM) for 30 min before the Phe-contraction and ACh-induced relaxation. All data were expressed as mean ± SEM. n = 5, *P < 0.05 vs. Vehicle; #P < 0.05 vs. HG; †P < 0.05 vs. PCB2+HG; NS, not significant vs. PCB2+HG.