TABLE 5.

Examples of circulating miRNAs in MPM.

	Expression in MPM	Sample size	Sensitivity and specificity	References
miR-16	Downregulated	MPM patients (N = 32), Controls with non-cancerous pulmonary disease (N = 15), Asbestos-exposed (N = 14), MPM – FFPE (N = 24)	86.7% sensitivity, 82.2% specificity	Mozzoni et al. (45)
miR-17	Downregulated	MPM patients (N = 32), Controls with non-cancerous pulmonary disease (N = 15), Asbestos-exposed (N = 14), MPM – FFPE (N = 24)	80.0% sensitivity, 84.4% specificity	Mozzoni et al. (45)
miR-126	Downregulated	MPM patients (N = 44), Healthy volunteers (N = 50), Asbestos-exposed (N = 196)	80% sensitivity, 97.8% specificity (45); 73% sensitivity, 74% specificity (74)	Mozzoni et al. (45), Santarelli et al. (74)
miR-486	Downregulated	MPM patients (N = 32), Controls with non-cancerous pulmonary disease (N = 15), Asbestos-exposed (N = 14), MPM – FFPE (N = 24)	80.0% sensitivity, 89.1% specificity	Mozzoni et al. (45)