TABLE 2.
Univariate and multivariate analyses of survival in patients with CNS hemangioblastoma.
| Variable | Patients | 5-year survival rate (%) | Univariate survival |
Multivariate survival |
||
| HR (95% CI) | p | HR (95% CI) | p | |||
| Age | 2,059 | 88.8 | ||||
| ≤19 | 145 | 95.3 | 1 [Reference] | 1 [Reference] | ||
| 20–39 | 587 | 96.0 | 0.940 (0.455–1.945) | 0.868 | 0.902 (0.428–1.901) | 0.787 |
| 40–59 | 787 | 90.2 | 1.688 (0.849–3.352) | 0.135 | 1.411 (0.696–2.860) | 0.340 |
| 60–79 | 483 | 79.9 | 3.814 (1.929–7.539) | <0.001 | 3.697 (1.837–7.442) | <0.001 |
| ≥80 | 57 | 47.1 | 13.748 (6.530–28.945) | <0.001 | 12.318 (5.625–26.974) | <0.001 |
| Gender | 2,059 | 88.8 | ||||
| Female | 946 | 90.4 | 1 [Reference] | 1 [Reference] | ||
| Male | 1,113 | 87.2 | 1.250 (0.979–1.596) | 0.074 | 1.278 (0.979–1.668) | 0.072 |
| Race | 2,059 | 88.8 | ||||
| Caucasian | 1,632 | 88.9 | 1 [Reference] | 0.084 | 1 [Reference] | |
| African American | 203 | 83.1 | 1.401 (0.971–2.022) | 0.071 | 1.857 (1.237–2.786) | 0.003 |
| Other | 189 | 91.8 | 0.712 (0.440–1.152) | 0.166 | 0.937 (0.560–1.569) | 0.805 |
| Unknown | 34 | 90.2 | 0.516 (0.128–2.078) | 0.352 | 0.436 (0.061–3.130) | 0.436 |
| Marital status | 2,059 | 88.8 | ||||
| Married | 1,080 | 88.9 | 1 [Reference] | |||
| Unmarried | 855 | 87.8 | 1.202 (0.942–1.535) | 0.140 | ||
| Unknown | 124 | 92.1 | 0.732 (0.385–1.391) | 0.340 | ||
| Tumor size (cm) | 1,347 | 88.2 | ||||
| ≤2 | 402 | 87.7 | 1 [Reference] | |||
| 2–4 | 595 | 87.6 | 1.250 (0.874–1.787) | 0.211 | ||
| ≥4 | 350 | 89.8 | 1.020 (0.670–1.552) | 0.926 | ||
| Tumor location | 1,842 | 88.9 | ||||
| Cerebellum | 1,280 | 89.8 | 1 [Reference] | 1 [Reference] | ||
| Brainstem | 105 | 82.0 | 1.826 (1.144–2.913) | 0.012 | 2.075 (1.289–3.342) | 0.003 |
| Spinal cord | 295 | 90.0 | 1.078 (0.749–1.551) | 0.687 | 1.092 (0.755–1.581) | 0.640 |
| Cerebrum | 147 | 83.3 | 1.614 (1.064–2.447) | 0.024 | 1.520 (1.012–2.343) | 0.044 |
| Other | 14 | 92.9 | 1.223 (0.303–4.937) | 0.777 | 1.616 (0.397–6.581) | 0.503 |
| Tumor number | 2,059 | 88.8 | ||||
| Solitary | 1,579 | 90.0 | 1 [Reference] | 1 [Reference] | ||
| Multiple | 480 | 84.8 | 2.013 (1.574–2.574) | <0.001 | 1.715 (1.307–2.251) | <0.001 |
| Surgery | 2,053 | 88.7 | ||||
| No | 251 | 83.4 | 1 [Reference] | 1 [Reference] | ||
| Yes | 1,802 | 89.5 | 0.644 (0.471–0.880) | 0.006 | 0.638 (0.448–0.908) | 0.013 |
| GTR | 1,770 | 89.5 | ||||
| No | 805 | 87.5 | 1 [Reference] | |||
| Yes | 965 | 91.1 | 0.816 (0.624–1.068) | 0.139 | ||
| Radiotherapy | 2,052 | 88.8 | ||||
| No | 1,942 | 89.6 | 1 [Reference] | 1 [Reference] | ||
| Yes | 110 | 75.0 | 1.888 (1.259–2.831) | 0.002 | 0.928 (0.574–1.500) | 0.760 |