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. 2020 Sep 9;10:543562. doi: 10.3389/fonc.2020.543562

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Copyright © 2020 Zheng, Zhou, Qu, Ren, Yan, Guo and Yue.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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VEGFR2 inhibition decreases osteosarcoma cell invasion and migration. (A) Apatinib did not obviously influence KHOS and U2OS cell viability at concentrations of 0.5, 1.0, and 1.5 μM. Proliferation of these two cell lines in response to apatinib treatment was confirmed via cell colony formation analysis. (B) Both shNC and shVEGFR2 lentiviruses were transferred into KHOS and U2OS cells, following estimation of VEGFR2 expression via WB and RT-PCR. (C,D) Both apatinib treatment and VEGFR2 knockdown significantly attenuated the KHOS and U2OS cell migratory and invasive abilities, as demonstrated by a Transwell assay. (Magnification at 100×), (mean ± S.D., n = 3), ***p < 0.001.