Table 1.
Characteristics of the study cohort.
| All patients (n = 189) | Septic shock (n = 77) | Severe sepsis (n = 112) | ||||||
|---|---|---|---|---|---|---|---|---|
| Variable | N | % | N | % | N | % | p | |
| Gender | Male | 86 | 45.5% | 34 | 44.2% | 52 | 46.4% | 0.437 |
| Source of infection | Respiratory | 107 | 56.60% | 32 | 41.60% | 75 | 67.00% | 0.004 |
| Blood stream | 20 | 10.60% | 14 | 18.20% | 6 | 5.40% | ||
| Abdominal | 17 | 9.00% | 6 | 7.80% | 11 | 9.80% | ||
| Genitourinary | 10 | 5.30% | 4 | 5.20% | 6 | 5.40% | ||
| Skin/Soft tissue | 6 | 3.20% | 5 | 6.50% | 1 | 0.90% | ||
| CNS | 3 | 1.60% | 2 | 2.60% | 1 | 0.90% | ||
| Endocarditis | 1 | 0.50% | 1 | 1.30% | 0 | 0.00% | ||
| Unknown | 25 | 13.20% | 13 | 16.90% | 12 | 10.70% | ||
| Positive culture | Yes | 72 | 38.1% | 36 | 46.8% | 36 | 32.1% | 0.030 |
| Comorbidities | Yes | 151 | 79.9% | 64 | 83.1% | 87 | 77.7% | 0.233 |
| Mechanical ventilation | Yes | 106 | 56.1% | 63 | 81.8% | 43 | 38.4% | 0.000 |
| Mortality | Yes | 32 | 16.9% | 15 | 19.5% | 17 | 15.2% | 0.280 |
| Hospital-acquired infection | 44 | 23.3% | 16 | 20.8% | 28 | 25% | 0.310 | |
| Median | IQR | Median | IQR | Median | IQR | |||
| MODS | 3 | 2–4% | 3 | 3–4 | 2 | 1–3% | 0.000 | |
| PIM 3 | 3.97% | 1.46–3.99% | 5.54% | 1.46–15.3% | 3.63% | 1.45–10.07% | 0.155 | |
| Age (months) | 19 | 3–74.5% | 18 | 3–92 | 19.5 | 4.25–68.75% | 0.744 | |
| PICU LOS (days) | 8 | 2–23.5% | 10 | 4.5–28 | 6.5 | 2–17% | 0.050 | |
| Hospital LOS (days) | 22 | 9–30% | 30 | 10–30 | 19 | 9–30% | 0.085 | |
| VFD (days) | 23 | 0–28% | 0 | 0–23 | 28 | 17.5–28% | 0.000 | |
CNS, central nervous system; MODS, multiorgan dysfunction syndrome; PIM, Pediatric Index of Mortality; LOS, length of stay.