TABLE 3.
List of top enriched GO terms of 4 DEMGs groups.
| Category | Terms | ID | Description | Gene count | % | P value | Genes |
| Up-hyper genes | BP | GO:0034446 | Substrate adhesion-dependent cell spreading | 6 | 5.77 | 2.02E-05 | ABL1, CDC42, FER, FN1, MICALL2, TRIOBP |
| BP | GO:2000251 | Positive regulation of actin cytoskeleton reorganization | 3 | 2.88 | 1.52E-04 | ABL1, BAIAP2L1, CDC42 | |
| BP | GO:0042749 | Regulation of circadian sleep/wake cycle | 3 | 2.88 | 2.08E-04 | CHRNB2, NR1D1, PER3 | |
| BP | GO:0031532 | Actin cytoskeleton reorganization | 5 | 4.81 | 2.52E-04 | ABL1, BAIAP2L1, CDC42, FER, MICALL2 | |
| BP | GO:2000637 | Positive regulation of gene silencing by miRNA | 3 | 2.88 | 2.74E-04 | DDX5, STAT3, TRIM71 | |
| Up-hypo genes | CC | GO:0016323 | Basolateral plasma membrane | 11 | 6.01 | 6.06E-06 | ABCC1, AQP9, ATP6V1B1, B4GALT1, CD34, EZR, FLOT2, KCNQ1, MAP7, SLC19A1, SLC23A1 |
| CC | GO:0035579 | Specific granule membrane | 7 | 3.83 | 2.22E-05 | CD59, MMP25, MS4A3, PLAUR, PLD1, PTPRJ, VAMP1 | |
| CC | GO:0030667 | Secretory granule membrane | 12 | 6.56 | 2.33E-05 | B4GALT1, CD59, CEACAM6, FLOT2, ICA1, MMP25, MS4A3, PLAUR, PLD1, PTPRJ, SLC11A1, VAMP1 | |
| CC | GO:0033116 | Endoplasmic reticulum Golgi intermediate compartment membrane | 6 | 3.28 | 5.11E-05 | AREG, CD59, CSNK1D, ERGIC1, MPPE1, NAT8 | |
| BP | GO:0042119 | Neutrophil activation | 15 | 8.62 | 6.84E-05 | B4GALT1, CAP1, CD59, CEACAM6, CXCL6, IMPDH1, MMP25, MMP9, MPO, MS4A3, OLFM4, PLAUR, PLD1, PTPRJ, SLC11A1 | |
| Down-hyper genes | MF | GO:0003899 | DNA-directed 5′-3′ RNA polymerase activity | 3 | 3.53 | 9.99E-04 | CD3EAP, POLR3A, ZNRD1 |
| CC | GO:0030008 | TRAPP complex | 2 | 2.30 | 1.23E-03 | TRAPPC4, TRAPPC5 | |
| CC | GO:0055029 | Nuclear DNA-directed RNA polymerase complex | 4 | 4.60 | 1.29E-03 | CD3EAP, POLR3A, RPRD1A, ZNRD1 | |
| MF | GO:0034062 | 5′-3′ RNA polymerase activity | 3 | 3.53 | 1.31E-03 | CD3EAP, POLR3A, ZNRD1 | |
| MF | GO:0097747 | RNA polymerase activity | 3 | 3.53 | 1.31E-03 | CD3EAP, POLR3A, ZNRD1 | |
| Down-hypo genes | BP | GO:0034644 | Cellular response to UV | 4 | 5.80 | 2.40E-04 | CRIP1, DHX36, TREX1, TRIAP1 |
| BP | GO:0002244 | Hematopoietic progenitor cell differentiation | 5 | 7.25 | 3.71E-04 | C12orf29, DHX36, TCF12, TREX1, ZBTB24 | |
| BP | GO:0051281 | Positive regulation of release of sequestered calcium ion into cytosol | 3 | 4.35 | 4.33E-04 | F2RL3, P2RY6, TRPC1 | |
| BP | GO:0045668 | Negative regulation of osteoblast differentiation | 3 | 4.35 | 8.86E-04 | HOXA2, ID3, LIMD1 | |
| BP | GO:0010524 | Positive regulation of calcium ion transport into cytosol | 3 | 4.35 | 1.05E-03 | F2RL3, P2RY6, TRPC1 |