TABLE 4.
List of top enriched KEGG terms of 4 DEMGs groups.
| Category | ID | Description | Gene count | % | P value | Genes |
| Up-hyper genes | hsa04370 | VEGF signaling pathway | 5 | 9.80 | 3.44E-05 | AKT2, CDC42, KDR, PPP3CA, PTGS2 |
| hsa05206 | MicroRNAs in cancer | 8 | 15.69 | 7.21E-04 | ABL1, IRS2, MARCKS, PTGS2, RPS6KA5, SOX4, STAT3, TRIM71 | |
| hsa04722 | Neurotrophin signaling pathway | 5 | 9.80 | 9.38E-04 | ABL1, AKT2, CDC42, IRAK3, RPS6KA5 | |
| hsa04920 | Adipocytokine signaling pathway | 4 | 7.84 | 9.57E-04 | AKT2, IRS2, RXRG, STAT3 | |
| hsa05165 | Human papillomavirus infection | 8 | 15.69 | 1.08E-03 | AKT2, CDC42, FN1, ITGB4, MAML2, MAML3, PTGS2, THBS4 | |
| Up-hypo genes | hsa04140 | Autophagy - animal | 7 | 7.87 | 8.25E-04 | ATG16L2, CAMKK2, CFLAR, KRAS, PPP2CA, PTEN, TP53INP2 |
| hsa04977 | Vitamin digestion and absorption | 3 | 3.37 | 2.32E-03 | ABCC1, SLC19A1, SLC23A1 | |
| hsa04710 | Circadian rhythm | 3 | 3.37 | 4.87E-03 | BHLHE40, CSNK1D, PER1 | |
| hsa04151 | PI3K-Akt signaling pathway | 10 | 11.24 | 6.00E-03 | AREG, CSF3R, IFNAR2, KIT, KRAS, MYB, PIK3R6, PPP2CA, PTEN, SGK1 | |
| hsa05221 | Acute myeloid leukemia | 4 | 4.49 | 6.59E-03 | KIT, KRAS, MPO, RUNX1 | |
| Down-hyper genes | hsa03020 | RNA polymerase | 2 | 7.41 | 4.87E-03 | POLR3A, ZNRD1 |
| hsa03460 | Fanconi anemia pathway | 2 | 7.41 | 1.43E-02 | FANCF, FANCL | |
| Down-hypo genes | hsa00514 | Other types of O-glycan biosynthesis | 2 | 6.90 | 1.21E-02 | GALNT3, LFNG |
| hsa04623 | Cytosolic DNA-sensing pathway | 2 | 6.90 | 2.19E-02 | AIM2, TREX1 | |
| hsa03015 | mRNA surveillance pathway | 2 | 6.90 | 4.31E-02 | PPP2R2B, RNGTT | |
| hsa03450 | Non-homologous end-joining | 1 | 3.45 | 4.65E-02 | RAD50 |