TABLE 5.

ROC analysis based on the expression and methylation status of hub genes.

Hub gene	Classification	AUC	95% CI	P value	Se (%)	Sp (%)
FN1	Expression	0.738	0.614–0.861	0.002	93.333	43.333
	Methylation	0.839	0.740–0.938	<0.001	86.667	70.000
	Combination	0.894	0.801–0.987	<0.001	95.000	75.000
PTEN	Expression	0.776	0.656–0.895	<0.001	93.333	56.667
	Methylation	0.683	0.549–0.817	0.015	76.667	53.333
	Combination	0.856	0.746–0.967	<0.001	90.000	66.667
POLR3A	Expression	0.691	0.558–0.824	0.011	36.667	96.667
	Methylation	0.662	0.525–0.800	0.031	96.667	36.667
	Combination	0.779	0.645–0.913	0.002	80.000	66.667

AUC, area under the receiver operating characteristic curves; Se, sensitivity; Sp, specificity.