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. Author manuscript; available in PMC: 2021 Aug 1.
Published in final edited form as: Pain. 2020 Aug;161(8):1906–1924. doi: 10.1097/j.pain.0000000000001884

Figure 3: A-fiber input to DYN interneurons increases throughout postnatal development.

Figure 3:

A) Schematic illustrating the use of patch clamp recordings in the intact spinal cord preparation while stimulating the sciatic nerve with attached dorsal roots (L3 and L4). B) Plot of the distribution of monosynaptic primary afferent input to lamina I DYN interneurons throughout development. Data are presented as the percentage of sampled DYN neurons at a given age that received each type of monosynaptic input (note that some neurons received more than one type of direct input). At P6–7, cells receive low- or high-threshold C fiber input, while direct A fiber input was only recorded in cells from P21–22 and P49–63 mice (n = 13–15 neurons per age group).