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. 2020 Jun 9;10(4):829–851. doi: 10.1016/j.jcmgh.2020.06.001

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© 2020 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Effects of PF-05221304 on de novo lipogenesis, fatty acid oxidation, and triglyceride accumulation in primary human hepatocytes. (A) PF-05221304 suppressed DNL, as assessed by incorporation of ¹⁴C acetate into lipids in a concentration-dependent manner. (B) PF-05221304 (closed circles) stimulated hepatocyte fatty acid oxidation relative to vehicle (open circles) as measured by production of ³H₂O from ³H-palmitate. (C) Accumulation of total hepatocyte triglyceride levels were suppressed by PF-05221304 (closed circles) relative to vehicle (open circles). (D) Relative to vehicle, PF-05221304 suppressed levels of total triglycerides, tripalmitin (Tri-16:0), and tristate (Tri-18:0), but not trilinolein (Tri-18:2). ∗P < .05 relative to vehicle. ∗∗∗P < .001 relative to vehicle.